Evaluation of IGH partitioning utilities

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Stanford_S22 genotype

The genotype for the Stanford_S22 dataset was independently inferred using iHMMune-align, IgBLAST and IMGT/V-QUEST+JunctionAnalysis using the method described in Boyd, 2010. A list of the IGHV, IGHD and IGHJ genes that were inferred as comprising the genotypes are in the tables below.

The Stanford_S22 rearrangeable genes lend themselves to the evaluation of IGH utilities as the genotype lacks a number of IGHD genes (IGHD1-7, IGHD3-3, IGHD2-8, IGHD4-4, IGHD6-25, IGHD6-6), and is homozygous for the IGHD genes that are present. This allows the identification of IGHD genes at the gene and allele level to be evaluated in a variety of IGH rearrangements.

Stanford_S22 rearrangeable IGHV genes

Table 1: Inferred IGHV genotype for Stanford_S22

Stanford_S22 rearrangeable IGHD genes

Table 2: Inferred IGHD genotype for Stanford_S22

Stanford_S22 rearrangeable IGHJ genes

Table 3: Inferred IGHJ genotype for Stanford_S22

Additional genotypes

Additional genotypes will be added to the evaluation utility as they become available.
IGH utility evaluation
iHMMune-align
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For queries about iHMMune-align:
Andrew Collins
Katherine Jackson